Injection of HET0016, a selective CYP450 inhibitor required for 20‐HETE production, for 4 consecutive days in wild‐type mice, resulted in an approximately 70% reduction in serum levels of 20‐HETE which was associated with glucose intolerance and reduced glucose‐stimulated insulin secretion (Appendix Fig S2B and C, Fig 7C), but did not alter the morphology of pancreatic islets (Appendix Fig S2D and E). The gene discussed is INS; the disease is Glucose intolerance.