Importantly, GPVI depletion by JAQ1‐IgG or GPVI‐blockade by JAQ1‐F(ab)2, blockage of GPIIb/IIIa by JON/A‐F(ab)2, or systemic platelet depletion using R300 antibody also caused glucose intolerance in male mice resulting from decreased insulin secretion in response to glucose, while insulin sensitivity was not affected (Fig 4A–I). Here, INS is linked to Glucose intolerance.