Within MCI-AD Aβ42/40 (r = 0.04, p = 0.813) and GFAP (r = −0.23, p = 0.121) were not significantly associated with baseline ACE-R, but p-tau181 (r = −0.42 p = 0.007), and NfL (r = −0.48, p = 0.005) log concentrations held moderately significant correlations with greater disease severity. The gene discussed is NEFL; the disease is Alzheimer disease.