NEFL and Alzheimer disease: Glial fibrillary acidic protein (GFAP), a protein expressed by astrocytes and possible marker of astrocytosis/astrocytic activation (Liddelow & Barres, 2017), and neurofilament light chain (NfL), a marker of neuroaxonal injury (Karlsson, Rosengren, & Haglid, 1991), are elevated in several neurological diseases including, but not limited to AD and Lewy body disease (Gaetani et al., 2019; Schulz et al., 2021).