STUB1 and ischemia: They showed that mice with either transverse constriction of the aorta (ie, pressure overload) or ligation of the anterior descending artery (ie, ischemia) had a comparable cardiac macrophage‐led inflammation profile with an inflammasome‐dependent immune response with IL‐1 and IL‐6,11, 12 strengthening the similarities between CHIP‐associated ischemic HFrEF and CHIP‐associated nonischemic HFrEF.