Tet2‐deficient macrophages in the atherosclerotic plaque produce more IL‐1 and IL‐6 when stimulated with low‐density lipoprotein compared with macrophages without Tet2 mutations,2, 51 suggesting that hypercholesterolemia may increase the proinflammatory effects of CHIP. This evidence concerns the gene TET2 and Hypercholesterolemia.