TNF and heart failure: TNF‐α itself drives clonal expansion with myeloid skewing at least in an in vitro setting,95 and an increase in TNF‐α was also observed in circulating monocytes of patients with heart failure (including aortic stenosis patients) with DNTM3A CHDMs, as well as in pressure‐overload mice models with Jak2 CHDMs.12, 79