It has been reported that dysregulation and malfunction of WNT co-receptor, LRP6 is associated with the development of AD in multiple ways, including inhibition of LRP6 expression by APOE4, decreased LRP6 interaction with APP promotes Aβ production and splicing of LRP6 by single nucleotide polymorphisms (SNPs) [57,71,72]. The gene discussed is LRP6; the disease is Alzheimer disease.