PSEN1 and Alzheimer disease: Alzheimer’s disease is accompanied by cognitive and memory deficits due to the accumulation of amyloid-β (Aβ) and tau-containing neurofibrillary tangles, oxidative stress, inflammation, mitochondrial dysfunction, and mutations on chromosomes such as APP (chromosome 21), presenilin 1 (chromosome 14), presenilin 2 (chromosome 1), and APOEe4 gene chromosome 19 result in the formation of Aβ plaques, by interfering with γ secretase [29,30,31,32,33,34,35,36].