MAPT and Alzheimer disease: Comprehensively, WβC signaling promotes neurogenesis and prevents neuronal loss in AD in multiple ways, including inhibition of tau phosphorylation, Aβ production, DKK1 suppression, GSK3β inhibition, APP suppression, BBB integrity enhancement, BACE1 inhibition, increased expression of NeuroD1 and surviving, and neuroinflammation inhibition, which eventually enhances synaptic plasticity in animal models as well as in AD patients [28] (Figure 2).