CLCA1 and fungal infectious disease: One indication of fungal infection-induced epigenetic changes could be extrapolated from the funding by Perez FJ et al. They showed that fungal colonization with Pneumocystis has been shown to elevate the concentration of chloride channel accessory 1 (hCLCA1) in the infant lung parenchyma, and it also correlates with overproduction of mucin 5 AC (MUC5AC) [92].