Among them, TH006, with (b) the ALAPYIP sequence as a VHL ligand (Figure 6), demonstrated the highest tau degradation in in vitro assay using tau-overexpressed SH-SY5Y cells, and furthermore, it reduced the toxicity of amyloid β (Aβ), and lowered the tau level in an AD mouse model [19]. The gene discussed is VHL; the disease is Alzheimer disease.