An ABC scoring system uses four-point scales (0–3) where “A” correlates with “amyloid” or Thal phase, “B” correlates with tau or “Braak” stage, and “C” corresponds to neuritic plaque density in the neocortex based on the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) score [38,39]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.