An ABC scoring system uses four-point scales (0–3) where “A” correlates with “amyloid” or Thal phase, “B” correlates with tau or “Braak” stage, and “C” corresponds to neuritic plaque density in the neocortex based on the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) score [38,39]. Here, MAPT is linked to Alzheimer disease.