In a separate study examining the effect of the R47H variant on tau pathology in the PS19 mouse model of tauopathy expressing either human common TREM2 or the R47H variant, it was discovered that impaired TREM2 signaling (in the case of the R47H variant) significantly attenuated neurodegenerative changes caused by tau pathology. The gene discussed is TREM2; the disease is tauopathy.