IES-R scores did not differ for overall score nor for other distress categories (p > 0.05) between disease categories (i.e., presence of distress symptoms in chronic glaucoma n = 10, 32%, wet AMD requiring anti-VEGF injections n = 5, 15%, PDR n = 6, 16%, or chronic uveitis n = 6, 14%; p = 0.19). The gene discussed is VEGFA; the disease is wet macular degeneration.