MAPT and Alzheimer disease: A recent PET study in a population with MCI and amyloid-PET biomarker positivity has additionally demonstrated a significant association between increased amyloid burden and AES score independent of regional FDG metabolism [180], whilst an exploratory PET study of AD-MCI and early AD dementia has demonstrated tau in small clusters within the right ACC and DLPFC, more pronounced in those with higher levels of amyloid accumulation [181].