NAFLD: nonalcoholic fatty live disease; NASH: nonalcoholic steatohepatitis; BMI: body mass index; ALT: alanine transaminase; AST: aspartate transaminase; TG: triglyceride; TC: total cholesterol; LDL-C: low-density lipoprotein-cholesterol; MS: metabolic syndrome; RCCT: randomized control clinical trials. The gene discussed is GPT; the disease is metabolic dysfunction-associated steatotic liver disease.