Based on the current analysis, combined ALP, CRP, and Hb with ESR were the most accurate for predicting bone metastases and SREs. To investigate the predictive accuracy of combining risk factors for SREs in patients with advanced RCC with bone metastasis, ROC analysis was conducted for a different combination of risk factors (Figure 2A-2C). The gene discussed is GSTM1; the disease is renal cell carcinoma.