ESR1 and bone metastasis: The cut-off values of ALP, CRP, Hb and ESR for the prediction of bone metastasis were >236 U/ml (AUC .849, p=.01), >84 μg/ml (AUC .856, p=.021), <10.5 g/l (AUC .765, p=.045) and 74 mm/hour (AUC .880, p=.032), respectively (Figure 1).