Another study proved that in HCC, SSD controls HCC cell proliferation by inhibiting the phosphorylated signal transducer and activator of transcription 3 CCAAT/enhancer binding protein beta (p-STAT3/C/EBPβ) signaling pathway and inhibits cyclooxygenase-2 (COX-2) expression. This evidence concerns the gene STAT3 and hepatocellular carcinoma.