Inclusion:1. Children 6–21 years with known history of IgE‐mediated milk allergy2. Pos SPT to milk extract (wheal ≥histamine control) or milk IgE levels >0.35kU/L3. Pos milk challenge at baseline (cum 2.5 gm milk protein)Exclusion:1. History anaphylaxis requiring hospitalization2. History of asthma intubation3. Current severe or persistent asthma. The gene discussed is IGHE; the disease is anaphylaxis.