AKT1 and head and neck squamous cell carcinoma: The members of the PI3K/Akt/mTOR axis interact with and contribute to the regulation of several other signaling molecules in HNSCC, including tumor suppressor protein p53, nuclear factor-kappa B (NF-κB), and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) [38].