Interestingly, at least five regions among the 24 identified by GWAS as critical for COVID-19 susceptibility are linked to the type I IFN pathway (TYK2, IFNAR1, OAS1, OAS2, OAS3 loci), and in 2 of them (TYK2 and IFNAR1) rare predicted loss of function variants (pLOFs) have been identified in COVID-19 [75, 81, 82] (Fig. 3). This evidence concerns the gene TYK2 and COVID-19.