Several human genetic studies carried out by the CHGE Consortium (Covid Human Genetic Effort, https://www.covidhge.com/about) have identified and characterized rare mutant alleles of these genes that confer susceptibility to COVID-19 and established causal connections between function variants of TLR7 and TRL3 genes and severe COVID-19 phenotype [75–77]. This evidence concerns the gene TLR7 and COVID-19.