FN1 and neoplasm: Particularly, tumor-derived exosomes were reported to educate hepatic stellate cells (HSCs) and Kupffer cells (KCs) to secrete fibronectin and transforming growth factor-β, respectively, thereby creating a fibrotic and immunosuppressive microenvironment at the metastatic site [160, 161]. These secreted factors help to recruit bone marrow-derived macrophages to hepatic PMNs (Fig. 1F).