Moreover, Bcl-xL regulates in vitro endothelial cell function and in vivo vessel formation in melanoma, through the nuclear factor κB (NF-κB)/IL-8 axis, underling the importance of Bcl-xL as a key regulator of the crosstalk between tumor and neo-vascular endothelial cells [20]. The gene discussed is BCL2L1; the disease is neoplasm.