By using in vitro and in vivo models, in this work we described how Bcl-xL overexpressed by melanoma cells, has a high relevance in the macrophage’s polarization and their recruitment, thanks to the release of cytokines such as IL-8 and IL-1β that are able to induce macrophage polarization, and C-C motif chemokine ligand 5 (CCL5, also known as RANTES) that is mainly involved in macrophage recruitment. The gene discussed is BCL2L1; the disease is melanoma.