Among the different members of Bcl-2 family, Bcl-xL belongs to those proteins that, not only play a pro-survival and an anti-apoptotic role but are, at the same time, capable of inducing tumor aggressiveness, such as tumor invasion/migration, epithelial mesenchymal transition, metastasization and stemness [18]. The gene discussed is BCL2L1; the disease is neoplasm.