Importantly, M-DM (Fig. 4C) and THP-1 (Supplementary Fig. 3B,C) cells show a significantly reduced migration when exposed to CM from melanoma cells overexpressing Bcl-xL treated with CCL5 blocking antibody, and compared to cells exposed to CM from Bcl-xL overexpressing cells treated with control siRNA. Here, CCL5 is linked to melanoma.