As up-regulated genes (IL-8, IL-1β, MCSF and CCL5) in Bcl-xL overexpressing melanoma cells have in common that are all regulated by NF-κB [20, 21], we evaluated if this transcription factor was the intermediary between Bcl-xL and the release of these cytokines. This evidence concerns the gene CXCL8 and melanoma.