ANGPT2 and neoplasm: As we also demonstrated that melanoma specific Bcl-xL induced the expression of Angiopoietins 1 and 2, the ligands of Tie-2 receptor, we cannot exclude that other cytokines, positively regulated by Bcl-xL such as angiopoietin-2, could play a role in macrophage functions, through their ability to enhance tumor-infiltration and proangiogenic or immunosuppressive activities of TIE2-expressing macrophages (TEMs) [36, 37].