Moreover, stronger evidence from CeD animal model confirmed that the GSDMD-FL and cleaved body GSDMD-C levels were higher in the IFN-γ/gliadin group than in the control counterpart, and the increasing cleaved caspase-1 and IL-1β directly verified the occurrence of pyroptosis (Fig. 8C). This evidence concerns the gene IL1B and cranioectodermal dysplasia.