Therefore, we considered that the targets enriched in the IL-17 signaling pathway including CXCL10, CSF3, MMP13, CCL7, MMP3, LCN2, TNFAIP3, CCL2, CXCL1, and PTGS2 were targets for J-NE against CGN. The gene discussed is CSF3; the disease is childhood gender nonconformity.