In this study, we have found that THD, a repurposed drug has the potential to be used for CRC treatment since 1) THD induces ER stress through eIF2α/ATF4/CHOP axis and secretory autophagy 2) enhances the ICD-inducing effect of chemotherapy and 3) induce apoptosis selectivity toward cells that exhibit Wnt/β-catenin activation and belong to the MSS classification. The gene discussed is DDIT3; the disease is colorectal carcinoma.