The odds ratio (OR) of Q4 is 1.28 (95% CI, 1.16–1.40), 1.28 (95% CI, 1.16–1.42), and 1.27 (95% CI, 1.17–1.43), respectively, in the model 1 (no adjustment), model 2 (adjusted for age, sex, and race), and model 3 (adjusted for age, sex, race, smoking, alcohol drinking, diabetes, hypertension, stroke, osteoarthritis, osteoporosis, CKD, COPD, HbA1c, glucose, ALT and AST). The gene discussed is GPT; the disease is chronic obstructive pulmonary disease.