Bioinformatics analysis found that the expression of COG1, MFSD11 and DEDD2 was positively correlated with JMJD6 and the poor prognosis of ESCC, which further proved the role of JMJD6 in the biological behavior of ESCC and deserved further exploration. The gene discussed is COG1; the disease is esophageal squamous cell carcinoma.