Univariate analysis showed that JMJD6 expression (HR = 2.282 [1.509–3.451], p < 0.001), lymphatic metastasis (HR = 1.806 [1.204–2.710], p = 0.004), and tumor-node-metastasis (TNM) stage (HR = 1.731 [1.150–2.605], p = 0.008) were associated with ESCC patients’ survival (Table 1). This evidence concerns the gene JMJD6 and esophageal squamous cell carcinoma.