Gene enrichment analysis showed that proteins co-expressed with JMJD6 were strongly associated with tumor progression, such as BRD4, MED12, CDK9, KDM8, TP53 and etc. Kaplan-Meier Plotter website was used to explore the prognostic value of the top 20 genes similar to JMJD6, and 5 genes were found to be statistically significant, all of which were positively correlated with JMJD6 expression in ESCA. The gene discussed is BRD4; the disease is neoplasm.