A high expression of Conserved oligomeric Golgi 1(COG1) (HR = 2.26 [1-5.12], Logrank p = 0.045), Major facilitator superfamily domain 11 (MFSD11) (HR = 3.47 [1.52–7.91], Logrank p = 0.0017), Death Effector Domain Containing 2 (DEDD2) (HR = 2.31 [1.03–5.16], Logrank p = 0.036) while a low expression of Small nucleolar RNA host gene 16 (SNHG16) (HR = 2.5 [1-5.9], Logrank p = 0.033), USP36 (HR = 2.86 [1.3–6.5], Logrank p = 0.0087) was related to a worse OS in ESCC patients (Fig. 3d). This evidence concerns the gene DEDD2 and esophageal squamous cell carcinoma.