In addition, inhibitors of Acyl Coenzyme A: Cholesterol Acyltransferases 1 (ACAT1), which also known as sterol O-acyltransferase 1 (SOAT1), could suppress tumor growth by downregulating cholesterol esterification (CE) in leukemia and triple-negative breast cancer [45, 70]. This evidence concerns the gene ACAT1 and leukemia.