To explore whether obR-b mediates the function of leptin, female db/db mice, which were considerably obese and lacked the long obR isoform (obR-b) (Lu et al. 2006), were used to generate a neutrophilic airway inflammation mouse model, as shown in Fig. 4a. Here, LEP is linked to Segmented Neutrophils to Neutrophils Ratio Measurement.