We explored the interaction between leptin/obR signaling and M1 macrophage polarization in obesity-related neutrophilic airway inflammation using a lipopolysaccharide (LPS)/ovalbumin (OVA) + OVA-treated obese mouse model, which has features similar to those of obesity-related asthma. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.