In primary tumors, EREG+ macro (M07) expressed increased levels of CXCL10/11, whereas C3+ macro (M12) highly expressed CXCL12; however, in metastatic tumors, it was surprising to find that the dominant source of CXCL10/11 was switched from EREG+ M07 to C3+ M12 and C1QA+ M10 upregulated the expression level of CXCL12, indicating a reprogramming of macrophages in metastatic tumors. The gene discussed is EREG; the disease is metastatic neoplasm.