Notably, the LAMP3+ DC cluster was also annotated as ‘mregDC’ for its high expression of maturation and immunoregulatory marker genes (such as CCR7, IL12B, CD274, PDCD1LG2 and LAMP3), a cellular state induced upon uptake of tumor antigens26 (Extended Data Fig. 6a). Here, LAMP3 is linked to neoplasm.