Moreover, IL13RA1+ E02 expressed higher levels of SPARC, COL4A1, COL4A2, ANGPT2 and ITGB1 (Fig. 7f), genes involved in vasculature development, epithelial cell proliferation and migration pathways (Fig. 7g), suggesting that IL13RA1+ E02 could contribute to chemotherapy resistance by promoting tumor angiogenesis and migration. This evidence concerns the gene COL4A2 and neoplasm.