TIMD4 and neoplasm: Bulk RNA sequencing of tumor-bearing fate-mapping mice models also confirmed the upregulation of C1q genes, Fabp5 and RTM signature genes, including Timd4 and Cd163 in ascites-enriched embryonic macrophages (Fig. 5e and Extended Data Fig. 7h), further confirming that embryonic macrophages might be a major source of RTMs in the ascites of patients with OC.