Conversely, EREG+ TeMs (M07) exhibited high expression of chemokines like CCL20, CCL4, CXCL10, CXCL8 and angiogenesis-related gene VEGFA, as well as low expressions of HLA-related genes, resembling the SPP1+ TAM identified in CRC (Fig. 4a,c and Extended Data Fig. 6d). Here, SPP1 is linked to colorectal carcinoma.