AGT and cardiac hypertrophy: Cardiac TMEM117 overexpression deteriorated Ang-II-induced cardiac hypertrophy, as indicated by enlarged cardiomyocytes area, increased interstitial fibrosis and collagen deposition (Fig. 3A–D), as well as elevated HW/BW (Fig. 3E) and HW/TL ratios (Supplementary Fig. 2C).