These results are consistent with our findings that Ad-Btg2 increased Crebh gene expression and glucose production, resulting in impaired glucose tolerance (Fig. 3a–c), whereas Btg2- and Crebh-silenced db/db mice exhibited decreased gluconeogenic gene expression and reduced glucose production and glucose intolerance (Fig. 3d–i). Here, CREB3L3 is linked to Glucose intolerance.