PTPN1 and infectious disease: Biological pathways for genes near the targets of selection included genes that are involved in immune function (HLA-DRB1, FBXL7, and PLD1), metabolism (PLD1), cellular response to stimuli (TNIK), infectious disease (ADCY8), muscle contraction (ACTN2), and gene expression (PTPN1, ZNF717, and ZNF557).