PRLR and autosomal dominant retinitis pigmentosa: While it is known that oxidative stress is involved in most of the pathological states and diseases18, in the case of a PRLR, a fixed and potentially pathogenic genomic variant could disturb the modulation of the endocrine and autocrine effects of prolactin in normal tissue and cancer19, in the cases of RP3 and RP1, it would disturb the structure or function of a protein that localizes to the outer segments of rod photoreceptors, and that is essential for their viability, mutations in this gene cause autosomal dominant retinitis pigmentosa.