Biological pathways for genes near the targets of selection included genes that are involved in immune function (HLA-DRB1, FBXL7, and PLD1), metabolism (PLD1), cellular response to stimuli (TNIK), infectious disease (ADCY8), muscle contraction (ACTN2), and gene expression (PTPN1, ZNF717, and ZNF557). This evidence concerns the gene ACTN2 and infectious disease.