Sumatriptan is often positioned as a vasoconstrictor65, which is not quite correct, because the actual vasoconstriction was demonstrated in experiments on isolated arteries66–69 while the "vascular" mechanism of action of triptans in migraine is rather 5-HT1B-mediated restoration of the tone of dilated cranial arteries, more precisely, triptans do prevent their dilation69,70. Here, HTR1B is linked to migraine disorder.