SQSTM1 and amyotrophic lateral sclerosis: We previously showed that accumulation of cytotoxic aggregates alters CREB-dependent transcription of synaptic genes in C9orf72-mutant MNs [14] and our phosphoproteomic data highlighted increased levels of phospho-SQSTM1/p62Ser349 in ALS cultures (Supplementary Table 3, online resource).