Thus, even though with different magnitudes (Fig. 5d), DHA rescued the synaptic levels of SYP and the pro-apoptotic activation of the transcription factor c-Jun in a heterogeneous cohort of fALS-related MNs, providing crucial information on how convergent pathomechanisms might be beneficially targeted across the ALS spectrum. The gene discussed is JUN; the disease is amyotrophic lateral sclerosis.