MAPK8 and amyotrophic lateral sclerosis: Interestingly, SNARE and vesicles dynamics are also controlled by the c-Jun N-terminal kinase (JNK, aka MAPK8), which was the top candidate kinase associated with increased phospho-c-JunSer63 in ALS and whose activation has been associated with several stress conditions and neurodegenerative diseases [68, 85].