In fact, DHA treatment did not only elevate the SYP levels in mutant cultures (as well as Healthy ones), but it also exerted a neuroprotective effect by improving cell survival and reducing the phospho-c-Jun levels in ALS MNs, supporting the evidences that resolving synaptic impairments can efficiently contrast neuronal degeneration [4, 14, 65]. Here, JUN is linked to amyotrophic lateral sclerosis.