In fact, treating ALS-related MNs with DHA significantly reduced the leakage of LDH (Supplementary Fig. 25a, online resource), as well as the expression of the pro-apoptotic genes AEN, CASP3 and CFLAR (Supplementary Fig. 25b–d, online resource), whose expression was predicted to be controlled by Jun using the Harmonizome software [62]. Here, CASP3 is linked to amyotrophic lateral sclerosis.