The reader ALYREF and other regulators, such as YBX1, DNMT1, DNMT3B, NOP2, NSUN2 and NSUN7, were shown to be protective factors significantly associated with better OS in CRC patients, while other regulators, such as NSUN3-6, were shown to be risk factors for significantly poorer OS with the best expression cutoff point in the K-M method. This evidence concerns the gene DNMT1 and colorectal carcinoma.