Additionally, RNAseq-based Ingenuity Pathway Analysis (IPA) revealed that expression of BRD4-NUT causes significant up- and downregulation of multiple cellular pathways, many of which are related to cancer development and progression, including: VDR and RXR activation, GP6 signaling, epithelial-mesenchymal transition, Netrin-1 signaling, WNT signaling, Basal Cell Carcinoma and Glioblastoma Multiforme signaling30–34 (Fig. S4a). This evidence concerns the gene BRD4 and cancer.