In conclusion, our results verify the reno-protective potential of AEA against HgCl<sub>2</sub>-induced kidney injury by its anti-inflammatory, antioxidant, and anti-apoptotic capacities by modulating WNT-5A/BCL-2, IP3/NFATC1, HMGB-1/RAGE/NF-κB, caspase-1/IL-18, and caspase-3/BCL-2 cues. Here, HMGB1 is linked to medical procedure.