Given that IscU2 regulates not only α-KG catabolism but also many mitochondrial function-dependent cellular activities38, the partial rescue of IscU2 depletion-inhibited PDAC cell proliferation by TET3 depletion suggested multiple roles of IscU2, including suppression of α-KG-promoted DNA 5hmC in tumor promotion, and promotion of mitochondrial electron transfer coupled cancer cell proliferation39. The gene discussed is TET3; the disease is cancer.