GC and viral infectious disease: Hamsters carrying a larger 10-amino acid disruption in PCDH1, encompassing F83, D85, and additional interfacial residues that individually and collectively impacted Gn/Gc-PCDH1 binding, phenocopied PCDH1-KO hamsters in being fully resistant to lethal virus challenge (Fig. 8c), likely by further reducing receptor recognition and cellular susceptibility to viral infection in vivo, as observed in cell culture (Supplementary Fig. 8c).