PCDH1 and hantavirus infectious disease: More work is needed to test this idea as well as simpler (e.g., PCDH1 down-regulation) and more complex scenarios (e.g., Gn/Gc-induced changes in PCDH1 conformation or transmembrane signaling), through which hantavirus infection could perturb PCDH1’s endogenous functions in the mammalian airway.