To evaluate the effect of these EC1 residues on PCDH1’s receptor activity, we ectopically expressed EC1-‘murinized’ variants of human PCDH1 in PCDH1-knockout (KO) human osteosarcoma U2OS cells and tested their susceptibility to both, rVSVs bearing ANDV or SNV Gn/Gc, and the authentic agents. Here, PCDH1 is linked to osteosarcoma.