GLI1 and chondrosarcoma: Then, we collected 10 normal cartilages, 26 low-grade (I–II), 33 high-grade (III), as well as 25 dedifferentiated chondrosarcomas to detect the expression of GLI1, which has no significant difference between normal cartilage and low-grade chondrosarcoma, but obviously increased in high-grade and dedifferentiated chondrosarcoma in our IHC staining (Fig. 1F, G).