CD4 and Sepsis: The recovery of DCs number and function by targeting these molecules is a promising mean to reduce mortality in COVID-19 related sepsis [27], while CD4+ and CD8 + T cells are responsible for SARS-CoV-2 clearance via MHC-II and MHC-I, respectively, and B cell-produced antibodies are enhanced by CD4 + T cells, further promoting CD8 + T-cell-mediated cytotoxicity [28–31].