Neuroinflammation, oxidative stress, and mitochondrial dysfunction lead to aggregation of misfolded protein (Aβ and tau, α-Syn, and TDP-43 [TAR DNA-binding protein] and SOD-1[superoxide dismutase] are the proteins involved in AD, PD, and ALS, respectively) which could trigger each disease [48]. The gene discussed is MAPT; the disease is Alzheimer disease.