SNCA and Parkinson disease: Potential intermediate filament requirements in exophergenesis were an initial focus given that in humans, circulating IFs are clinical biomarkers of human neurodegenerative disease36, and IFs are major components of α-synuclein-containing Lewy bodies that characterize Parkinson’s disease neuropathology37,38, features that might intersect with extrusion biology and proteostasis balance.