Indeed, myeloid lineage cells, such as macrophages and dendritic cells, are major components of a patient’s TME that are recapitulated in our approach, and these innate immune cells have drastic and varied effects on tumor growth as well as immune function25 26 Our single cell transcriptomic analyses pointed to the myeloid compartment as producers of VEGF-A in the TME, a central protumor cytokine. This evidence concerns the gene VEGFA and neoplasm.