By engrafting mice with BM derived stem cells followed by implantation of tumor derived from the same donor, we have demonstrated that autologous MISTRG6 models recapitulate important features of the human TME, including sufficient immunosuppression to prevent tumor clearance, presence of activated/exhausted-like T cells, and harboring innate immune cells including DCs, monocytes, NK cells, and macrophages, the latter being especially relevant by the production of VEGF-A. This evidence concerns the gene VEGFA and neoplasm.