VEGFA and neoplasm: Thus, we treated autologous mice humanized with HSPCs and PDXs from Mel2 with the anti-human-VEGF-A antibody bevacizumab that has high affinity for human VEGF-A yet low affinity for mouse VEGF-A and which does not affect tumor growth in non-engrafted hosts.10 21 The Mel2 PDXs grown in autologously engrafted MISTRG6 mice grew significantly larger than those in non-engrafted littermate control hosts.