Although a profibrotic role of these proteins was observed in some studies in the context of kidney, lung, and heart disease (30, 34, 35, 36), Bmal1 and Clock appear to exert a protective role in other studies related to kidney, lung, and liver fibrosis (11, 43, 45, 47, 48, 54). Here, BMAL1 is linked to Hepatic fibrosis.