The intraperitoneal administration of ibuprofen in PCS rats improved learning ability59, 60and motor activity.60, 61Ibuprofen restored the brain levels of prolyl oligopeptidase (PREP), decreasing the activity of iNOS and COX.59, 60, 61, 62Furthermore, PREP has been implicated in neuroinflammatory events in neurodegenerative diseases and seems to ameliorate the severity of neuroinflammation in patients with cirrhosis.62 This evidence concerns the gene PREP and Cirrhosis.