KCNA1 and episodic ataxia type 1: We focused our investigation on Kv1.1 channels carrying the V408A mutation (Kv1.1–V408A) since i) it was identified in patients with EA1 (7); ii) alters channel gating (8, 13, 35), and iii) a pertinent rodent model of EA1 has been generated by introducing a V408A mutation in the mouse genome (Kv1.1V408A/+) (10, 11), which enabled subsequent ex vivo and in vitro studies (see below).