HSPA5 and lung cancer: To rule out the off-target effect of the si78 against the 3′UTR, we utilized another siRNA targeting the coding region of the GRP78 gene to deplete GRP78 and observed that both siRNAs targeting different regions of the GRP78 gene were able to reduce EGFR protein levels in human lung cancer cell lines (SI Appendix, Fig. S1 C–E).