Despite its widespread use at present, there are only two case reports of ATIN associated with use of SGLT2is for standard indications.12,13 Assuming that the PD-L1/SGLT2 colocalization on tumor cells is present in vivo in humans, one potential explanation for this may be that the interaction between PD-L1 and SGLT2 as observed by Ding and colleagues is unique to cancer cells. This evidence concerns the gene SLC5A2 and cancer.