SLC5A2 and acute kidney injury: Acute tubulointerstitial nephritis (ATIN) is the most common kidney biopsy-proven finding in ICPI-AKI, resulting in treatment disruption and corticosteroid administration.11 ICPI-AKI may lead to residual CKD and may recur on ICPI rechallenge.11 Thus, the pivotal question for nephrologists is whether SGLT2-mediated inhibition of immune checkpoints would lead to ATIN as seen with ICPIs.