Intriguingly, a new study by Ding and colleagues offers the novel finding that SGLT2 may promote tumor growth through increased expression of the inhibitory immunoreceptor programmed death protein ligand 1 (PD-L1).8 In looking for novel PD-L1 inhibitors, they screened 98 clinically approved small molecule drugs on a patient-derived non–small cell lung cancer cell line with high PD-L1 expression. Here, CD274 is linked to lung cancer.