C3 and IgA glomerulonephritis: But antithrombotic agents have been widely applied to patients with IgA nephropathy in China and Japan (Table 8).150 Several multicenter randomized controlled trials found that anticoagulants/antiplatelet drugs significantly ameliorated renal injury caused by IgA immune complex deposition (Table 8).138,150 These effects may be related to the downregulation of MPs by anticoagulants/antiplatelet drugs because MPs could also bind to complement C3 and induce proinflammatory cytokines in IgA nephropathy.151