EPO and anemia: Estrogen can also be used, which inhibits the production and release of nitric oxide from vascular endothelial cells, thus enhancing platelet–vessel wall interaction.75 For coagulation disorders, infusion of cryoprecipitate is always applied because it is rich in coagulation factor VIII, fibrinogen, fibronectin, and vWFs.76 Desmopressin is also an ideal choice because it can stimulate the release of vWFs.77 For anemia, transfusion of packed erythrocytes or application of recombinant erythropoietin can be chosen.