Furthermore, we establish the translational potential of these findings by demonstrating that the HDACi CI-994 can both increase in vivo uptake of 177Lu-DOTATATE and, for the first time, confirm the concomitant therapeutic efficacy of PRRT with 177Lu-DOTATATE in a preclinical model of SSTR2-deficient pancreatic NETs (PNET). Here, SSTR2 is linked to pancreatic neuroendocrine tumor.