Out of these 6 autism-related genes, only 3 (CPT2, SCP2 and SSBP3) have strong orthologs in flies (DIOPT Score >0.5, S1 Table), with the highest orthology for SSBP3 (DIOPT Score = 0.93) (Fig 1B and S1 Table). The gene discussed is CPT2; the disease is autism.