In this research, we pointed out that some genes are more biased towards males, for example, deletion in PHF2 (ENSG00000197724), duplication in NRXN1 (ENSG00000179915), and deletions in WDFY3 (ENSG00000163625), PHF3 (ENSG00000118482), MED13L (ENSG00000123066), and WAC (ENSG00000095787), are more frequently seen in males than females for the developmental delay. This evidence concerns the gene WDFY3 and Global developmental delay.